The works selected comprise a variety of international, alternative, and independent small-press comics artists, from engravings and early comics to single-panel work, graphic novels, manga, and trading cards, by artists such as Will Eisner, Tsutomu Nihei, Hariton Pushwagner, Julie Doucet, Frans Masereel, and Chris Ware.

In the first monograph on this Subject, Fraser touches on many themes of modern urban life: activism, alienation, consumerism, flânerie, gentrification, the mystery story, science fiction, sexual orientation, and working-class labor. He leads readers to images of such cities as Barcelona, Buenos Aires, London, Lyon, Madrid, Montevideo, Montreal, New York, Oslo, Paris, São Paolo, and Tokyo.

Through close readings, each chapter introduces readers to specific comics artists and works and investigates a range of topics related to the medium's spatial form, stylistic variation, and cultural prominence. Mainly, Fraser mixes interest in urbanism and architecture with the creative strategies that comics artists employ to bring their urban images to life.