This book provides substantial information on the structure and properties of Bombyx mori silk, different fabrication techniques, testing methods, as well as potential applications in tissue engineering and drug release. Unlike previous studies that focus on fabricating silk biomaterials using various techniques, this book focuses on silk itself. Based on a deeper understanding of silk, it develops Bombyx mori silk-based biomaterials with tunable performance by means of established techniques. These developments open a new world for readers in the biomaterials field and promote further studies of other tunable biomaterials. As such, it offers an invaluable guide for all readers interested in pursuing silk research, as well as those from a broad range of regenerative medicine fields.