Having learned natural remedies and midwifery from her mother, Grace seeks an opportunity to use her skills for the benefit of others. So when she and her sisters arrive at the Whitman mission in "Oregon Country," she decides to stay rather than push on.

With the help of Alex Armistead, a French-American fur trapper, Grace begins to provide care for her neighbors, including some of the native populace. But not everyone welcomes her skills--or her presence--and soon Grace finds herself and those she loves in more danger than she imagined possible.