This, the24th issue of Transactions on Large-Scale Data- and Knowledge-Centered Systems,contains extended and revised versions of seven papers presented at the 25thInternational Conference on Database and Expert Systems Applications, DEXA2014, held in Munich, Germany, in September 2014. Following the conference, andtwo further rounds of reviewing and selection, six extended papers and oneinvited keynote paper were chosen for inclusion in this special issue. Topicscovered include systems modeling, similarity search, bioinformatics, datapricing, k-nearest neighbor querying, database replication, and dataanonymization.