This issue of Emergency Medicine Clinics, devoted to Seizures, will focus on topics such as: Seizure in the Emergency Department: Epidemiology and Cost to Society; Seizure and Status Epilepticus: Pathophysiology and Definitions; The Diagnosis and Management of Seizures and Status Epilepticus in the Pre-hospital Setting; The Emergency Department Evaluation of the Patients Who Present with a First Time Seizure; Generalized Convulsive Status Epilepticus: Treatment Guidelines and Protocols; Nonconvulsive Status Epilepticus; Antiepileptic Drugs: The Old and the New; Seizures in Pregnancy/Eclampsia and Psychogenic Seizures.