This book presents the latest research on software engineering application in informatics. The fields of software engineering, informatics, computer science, and artificial intelligence are critical for study in the intelligent systems issue space.

This is the first part of the refereed proceedings of the 6th Computational Methods in Systems and Software 2022 (CoMeSySo 2022). The CoMeSySo 2022 conference, which is being hosted online, is breaking down barriers. CoMeSySo 2021 aims to provide a worldwide venue for debate of the most recent high-quality research findings.