This book focuses on soft computing and how it can be applied to solve real-world problems arising in various domains, ranging from medicine and healthcare, to supply chain management, image processing and cryptanalysis. It gathers high-quality papers presented at the International Conference on Soft Computing: Theories and Applications (SoCTA 2020), organized online. The book is divided into two volumes and offers valuable insights into soft computing for teachers and researchers alike; the book will inspire further research in this dynamic field.