This volume contains 68 papers presented at SCI 2016: First International Conference on Smart Computing and Informatics. The conference was held during 3-4 March 2017, Visakhapatnam, India and organized communally by ANITS, Visakhapatnam and supported technically by CSI Division V - Education and Research and PRF, Vizag. This volume contains papers mainly focused on smart computing for cloud storage, data mining and software analysis, and image processing.