SEEK (Science Exploration, Excitement, and Knowledge) is a 40-lesson curriculum in health and biomedical science for diverse 4th and 5th grade students. The curriculum presents scientific concepts, promotes investigative skills and healthy lifestyle choices, and introduces students to healthcare and scientific careers in the context of teaching about diseases and conditions that disproportionately affect minorities. The topics covered include nutrition and obesity, traumatic brain injuries, infectious diseases, environmental toxics, diabetes, heart disease, and genetics and sickle cell anemia. The curriculum was developed under a SEPA (Science Education Partnership Award) grant from the National Center for Research Resources at the National Institutes of Health.