The proceedings of the 2022 edition of the International Symposium of Robotics Research (ISRR) offer a series of peer-reviewed chapters that report on the most recent research results in robotics, in a variety of domains of robotics including robot design, control, robot vision, robot learning, planning, and integrated robot systems. The proceedings entail also invited contributions that offer provocative new ideas, open-ended themes, and new directions for robotics, written by some of the most renown international researchers in robotics.