Risk, Reliability and Safety contains papers describing innovations in theory and practice contributed to the scientific programme of the European Safety and Reliability conference (ESREL 2016), held at the University of Strathclyde in Glasgow, Scotland (25--29 September 2016). Authors include scientists, academics, practitioners, regulators and other key individuals with expertise and experience relevant to specific areas. Papers include domain specific applications as well as general modelling methods. Papers cover evaluation of contemporary solutions, exploration of future challenges, and exposition of concepts, methods and processes. Topics include human factors, occupational health and safety, dynamic and systems reliability modelling, maintenance optimisation, uncertainty analysis, resilience assessment, risk and crisis management.