This book constitutes the refereed post-conference proceedings of the 15th EAI International Conference on Quality, Reliability, Security and Robustness in Heterogeneous Networks, QShine 2019, held in Shenzhen, China, in November 2019. The 16 revised full papers were carefully reviewed and selected from 55 submissions. The papers are organized thematically in tracks, starting with mobile systems, cloud resource management and scheduling, machine learning, telecommunication systems, and network management.