This book presents the outcome of the European project "SERENA", involving fourteen partners as international academics, technological companies, and industrial factories, addressing the design and development of a plug-n-play end-to-end cloud architecture, and enabling predictive maintenance of industrial equipment to be easily exploitable by small and medium manufacturing companies with a very limited data analytics experience. Perspectives and new opportunities to address open issues on predictive maintenance conclude the book with some interesting suggestions of future research directions to continue the growth of the manufacturing intelligence.