This issue contains 16 peer-reviewed papers (invited and contributed) incorporating the latest developments related to synthesis, processing and manufacturing technologies of nanoscaled materials and systems including one-dimensional nanostructures, nanoparticle-based composites, electrospinning of nanofibers, functional thin films, ceramic membranes, bioactive materials and self-assembled functional nanostructures and nanodevices. These papers discuss several important aspects related to fabrication and engineering issues necessary for understanding and further development of processing and manufacturing of nanostructured materials and systems.