The 16 thoroughly revised and extended papers presented in this volume were carefully reviewed and selected from 76 submissions. They address some of the most relevant challenges being faced by researchers and practitioners in the field of model-driven engineering and software development and cover topics like language design and tooling; programming support tools; code and text generation from models, behavior modeling and analysis; model transformations and multi-view modeling; as well as applications of MDD and its related techniques to cyber-physical systems, cyber security, IoT, autonomous vehicles and healthcare.