Through Will's gentle and humorous narrative, we come to know Medicine River, a small Albertan town bordering a Blackfoot reserve. And we meet its people: the basketball team; Louise Heavyman and her daughter, South Wing; Martha Oldcrow, the marriage doctor; Joe Bigbear, Harlen's world-travelling, storytelling brother; Bertha Morley, who has a short fling with a Calgary dating service; and David Plume, who went to Wounded Knee. At the centre of it all is Harlen, advising and pestering, annoying and entertaining, gossiping and benevolently interfering in the lives of his friends and neighbours.