This book gathers original findings, both theoretical and experimental, related to various cutting-edge topics in the design and modeling of mechatronic systems, including multiphysics problems. It presents peer-reviewed papers from the first installment of the Mechatronics 4.0 workshop, which was jointly organized by the Laboratory of Mechanics, Modeling and Manufacturing (LA2MP), National School of Engineers of Sfax, Tunisia, and the QUARTZ Laboratory, Higher Institute of Mechanics of Paris, SUPMECA, France. The event follows in the tradition of the Workshop on Mechatronic Systems (JSM2014), organized by the same universities, while shifting the focus to the concept of Industry 4.0.