Divided into two volumes, the book begins with a pedagogical presentation of some of the basic theory, with chapters on biochemical reactions, diffusion, excitability, wave propagation and cellular homeostasis. The second, more extensive part discusses particular physiological systems, with chapters on calcium dynamics, bursting oscillations and secretion, cardiac cells, muscles, intercellular communication, the circulatory system, the immune system, wound healing, the respiratory system, the visual system, hormone physiology, renal physiology, digestion, the visual system and hearing.

New chapters on Calcium Dynamics, Neuroendocrine Cells and Regulation of Cell Function have been included.

Reviews from first edition:

Keener and Sneyd's Mathematical Physiology is the first comprehensive text of its kind that deals exclusively with the interplay between mathematics and physiology. Writing a book like this is an audacious act!

-Society of Mathematical Biology

Keener and Sneyd's is unique in that it attempts to present one of the most important subfields of biology and medicine, physiology, in terms of mathematical "language", rather than organizing materials around mathematical methodology.

-SIAM review