Introduction to Biomedical Engineering, Fourth Edition is a comprehensive survey text for biomedical engineering courses. It is the most widely adopted text across the BME course spectrum, valued by instructors and students alike for its authority, clarity and encyclopedic coverage in a single volume. Biomedical engineers need to understand the wide range of topics that are covered in this text, including basic mathematical modeling, anatomy and physiology, electrical engineering, signal processing and instrumentation, biomechanics, biomaterials science, tissue engineering and medical and engineering ethics. The authors tackle these core topics at a level appropriate for senior undergraduate students and graduate students who are either majoring in BME or studying it as a combined course with a related engineering, biology or life science, or medical/pre-medical course.