This book constitutes therefereed proceedings of the 18th International Conference on IntegerProgramming and Combinatorial Optimization, IPCO 2016, held in Liège, Belgium,in June 2016. The 33 full papers presented were carefully reviewed and selectedfrom 125 submissions. The conference is a forum for researchers andpractitioners working on various aspects of integer programming andcombinatorial optimization. The aim is to present recent developments intheory, computation, and applications in these areas. The scope of IPCO isviewed in a broad sense, to include algorithmic and structural results ininteger programming and combinatorial optimization as well as revealingcomputational studies and novel applications of discrete optimization topractical problems.