This book aims to demonstrate and detail the pervasive nature of Discrete Optimization. The handbook couples the difficult, critical-thinking aspects of mathematical modeling with the hot area of discrete optimization. It is done with an academic treatment outlining the state-of-the-art for researchers across the domains of the Computer Science, Math Programming, Applied Mathematics, Engineering, and Operations Research. The book utilizes the tools of mathematical modeling, optimization, and integer programming to solve a broad range of modern problems.