Ghost Recon: Marine One is about military treason and espionage. MI-45 references a secret congressional council, funding deep-cover black operations. This is a story about a secret military project genetically engineering hybrids and putting them into military service as presidential combat assassins. The hybrids uncover a major intelligence leak from the CIA to the Russian KGB and stop the leak. MI-45 congressional council funds this operation. The hybrids were kidnapped by the CIA and turned over to the Navy SEALs. But they originated at a secret Marine hybrid center.