Set against the sweeping, 170-year rise of the Clare Soap and Chemical Corporation is the contemporary story of Laura Bodey, a real-estate broker. Laura, her two teenage children, and her ex-husband all live in Lacewood. Illinois, a place that owes its very existence to the regional Clare factories that have nursed the town from nothing. The Clare Agricultural Division now sponsors every aspect of Lacewood, from the corn boil to the college library. But when a cyst on Laura's ovary turns malignant and the local industry is implicated, the insignificant individual and the corporate behemoth collide, forever changing the shape of American life.

Gain examines the runaway experiment of modern business and where that experiment has left us. Gain is at once Powers's most historically ambitious and his most accessible novel to date.