This volume includes 16 papers from the National Academy of Engineering's 2005 U.S. Frontiers of Engineering (USFOE) Symposium held in September 2005. USFOE meetings bring together 100 outstanding engineers (ages 30 to 45) to exchange information about leading-edge technologies in a range of engineering fields. The 2005 symposium covered four topic areas: ID and verification technologies, engineering for developing communities, engineering complex systems, and energy resources for the future. A paper by dinner speaker Dr. Shirley Ann Jackson, president of Rensselaer Polytechnic Institute, is also included. The papers describe leading-edge research on face and human activity recognition, challenges in implementing appropriate technology projects in developing countries, complex networks, engineering bacteria for drug production, organic-based solar cells, and current status and future challenges in fuel cells, among other topics. Appendixes include information about contributors, the symposium program, and a list of meeting participants. This is the eleventh volume in the USFOE series.