Overview

The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar­ maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera­ peutic entities, as evidenced by Sir James Black's H -receptor an­ 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex­ pected actions of use for the treatment of human disease states. Drugs that have been identified by this route include the antipsy­ chotic chlorpromazine and the putative anxiolytic buspirone. The events surrounding the process of drug discovery and de­ velopment are the theme of the present volume, which attempts to present, in a logical and lucid manner, the complexity of a process that is often naively assumed to represent nothing more than the identification of a new compound and its rapid introduction into humans, free of such complications as efficacy, selectivity, safety, bioavailability, toxicity, and need.
ISBN-13

9781461291800

ISBN-10

1461291801

Weight

1.57 Pounds

Dimensions

6.10 x 1.06 x 9.25 In

List Price

$169.99

Edition

1st Edition

Format

Paperback

Language

English

Pages

xviii, 448 pages

Publisher

Humana

Published On

2011-09-30


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Alibris
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Sparks, NV, USA

Print on demand Trade paperback (US). Glued binding. 448 p. Contains: Unspecified.
$172.16

 Free delivery by: 31 Mar 2026


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