The focus of this book is an application of Digital Twin as a concept and an approach, based on the most accurate view on a physical production system and its digital representation of complex engineering products and systems. It describes a methodology to create and use Digital Twin in a built environment for the improvement and optimization of factory processes such as factory planning, investment planning, bottleneck analysis, and in-house material transport. The book provides a practical response based on achievements of engineering informatics in solving challenges related to the optimization of factory layout and corresponding processes.