Overview

Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergoes extreme antigenic variation, the mechanism of which is still poorly understood. Two kinds of antigenic variation occur in influenza viruses, antigenic drift and major antigenic shifts; both involve chan­ ges in the hemagglutinin and neuraminidase antigens on the surface of the virus. Antigenic drift, which involves gradual changes in the surface antigens of influenza virus, is thought to result from the selection by an immune popula­ tion of mutant virus particles with altered antigenic determinants. These mutants therefore possess a growth advantage in the presence of antibody (FRAN­ CIS and MAASSAB, 1965; ARCHETTI and HORSFALL, 1950; HAMRE et aI., 1958). It has been shown that antigenic mutants isolated in vitro by selection with antibody have changes in amino acid sequence in the polypeptides of the hem­ agglutinin subunits (LAVER and WEBSTER, 1968) and it is likely that antigenic drift in the neuraminidase occurs by the same mechanism.
ISBN-13

9783642654466

ISBN-10

3642654460

Weight

0.94 Pounds

Dimensions

6.69 x 0.60 x 9.61 In

List Price

$109.99

Edition

1st Edition

Format

Paperback

Language

English

Pages

iv, 258 pages

Publisher

Springer

Published On

2011-11-15


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Alibris
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Print on demand Trade paperback (US). Glued binding. 258 p. Current Topics in Microbiology and Immm...
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