Daniel Gerstein draws on twenty-nine years of experience in the security and defense sectors to address the threat of bioterrorism in the twenty-first century. He warns that while the proliferation of knowledge and capabilities in the field of biotechnology offers ever-increasing opportunities for scientific breakthroughs, the potential for the misuse of that knowledge also increases. Gerstein takes a classic game theory approach in his analysis of the potential for a bioterror attack in the future. His examination provides an objective capability for assessing threats, understanding emerging trends, and developing mitigation strategies. However, in the end the book is less about predicting future behavior than about understanding the framework in which dangerous capabilities are allowed to proliferate. The study also makes a valuable contribution to the debate over perceived threats and vulnerabilities in this new global environment.