Life is going damned well for Blair Spencer. She's a very successful real estate agent, happily married to a man who encourages her to live the independent life she loves--and they're actively working to have a baby.

The wrench in the works is that Blair favors adoption, while her husband David desperately wants to have a biological child. The fates are against them, and they finally seek the help of a group of reproductive specialists. One of the doctors, a surgeon named Kylie Mackenzie, eventually becomes a good friend to Blair. And she needs all of the friends she can get when things start to go horribly wrong at home. As her marriage teeters on the brink of collapse, she relies more and more on Kylie's friendship.

Kylie's happily gay; Blair's happily straight. But the way they structure their relationship leads friends and family to privately question whether the pair is setting themselves up for heartache. They eventually come to a crossroads, which could either destroy their friendship or turn it into what each of them has been seeking. The question is whether each woman can change her view of herself and her needs. The answer is all that matters.