The present volume gathers contributions to the conference Microlocal and Time-Frequency Analysis 2018 (MLTFA18), which was held at Torino University from the 2nd to the 6th of July 2018. The event was organized in honor of Professor Luigi Rodino on the occasion of his 70th birthday. The conference's focus and the contents of the papers reflect Luigi's various research interests in the course of his long and extremely prolific career at Torino University.