Advances in Human Genetics 10
by Harry Harris
Format: Paperback
ISBN13: 9781461582908
Paperback|9781461582908
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1 Biochemistry and Genetics of the ABO, Lewis, and P Blood Group Systems.- The ABO System.- The Lewis System.- The P System.- Serology and Genetics.- Chemistry of P1, P, and Pk Determinants.- Biosynthetic Pathways.- Relationship between ABH and P Systems.- Concluding Remarks.- References.- 2 HLA--A Central Immunological Agency of Man.- HLA: A Supergene.- HLA Terminology.- Inheritance of HLA.- The HLA-A, -B, and -C Allelic Series of Antigens.- HLA-D.- Cell-Mediated Lympholysis (CML).- HLA-DR.- Population Genetics.- The HLA "Supergene" and Transplantation.- Evolution and Maintenance of the MHC--Function?.- What of the Future?.- References.- 3 Linkage Analysis in Man.- General Considerations.- Historical Perspective.- Approach to Family Studies.- Preparation of Data Prior to Analysis.- Analysis of Data.- Interpretation of Results.- Multipoint Mapping.- Significance of Linkage.- References.- 4 Sister Chromatid Exchanges.- BrdUrd Methodology for SCE Detection.- Basic Information about SCEs.- Induction of Sister Chromatid Exchange by Clastogens.- Extension of SCE Studies from in Vitro to in Vivo Systems.- Interpretation of SCE Induction Tests.- Relationship of SCE Induction to DNA Damage, Repair, and Synthesis.- Relationship of SCE Induction to Mutagenesis.- Sister Chromatid Differentiation in Meiotic Cells.- Sister Chromatid Exchange Formation in Heritable Human Diseases.- Studies of the Mechanism of SCE Formation.- References.- 5 Genetic Disorders of Male Sexual Differentiation.- Normal Male Sex Differentiation in the Fetus.- Abnormal Male Sex Differentiation.- References.- Addenda.
| ISBN-13 | 9781461582908 |
|---|---|
| ISBN-10 | 1461582903 |
| Weight | 1.22 Pounds |
| Dimensions | 5.98 x 0.94 x 9.02 In |
| List Price | $54.99 |
| Edition | 1st Edition |
| Format | Paperback |
|---|---|
| Language | English |
| Pages | xviii, 394 pages |
| Publisher | Springer |
| Published On | 2012-01-24 |
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