This book explores facets of Otto Neugebauer's career, his impact on the history and practice of mathematics, and the ways in which his legacy has been preserved or transformed in recent decades, looking ahead to the directions in which the study of the history of science will head in the twenty-first century. Neugebauer, more than any other scholar of recent times, shaped the way we perceive premodern science. Through his scholarship and influence on students and collaborators, he inculcated both an approach to historical research on ancient and medieval mathematics and astronomy through precise mathematical and philological study of texts, and a vision of these sciences as systems of knowledge and method that spread outward from the ancient Near Eastern civilizations, crossing cultural boundaries and circulating over a tremendous geographical expanse of the Old World from the Atlantic to India.