Hennie Comfort is eighty-six and has lived in the mountains of Middle Swan, Colorado since before it was Colorado.  Nit Spindle is just seventeen and newly married.  She and her husband have just moved to the high country in search of work.  It's 1936 and the depression has ravaged the country and Nit and her husband have suffered greatly.  Hennie notices the young woman loitering near the old sign outside of her house that promises "Prayers For Sale".  Hennie doesn't sell prayers, never has, but there's something about the young woman that she's drawn to.  The harsh conditions of life that each have endured create an instant bond and an unlikely friendship is formed, one in which the deepest of hardships are shared and the darkest of secrets are confessed.