Reverend William Stryker, a religious zealot with a plan of genocide for mutants, attempted years ago to harness the telepathic abilities of Professor Charles Xavier in order to destroy the minds of mutants on a global scale. Only by uniting with Magneto, their ultimate enemy, were the X-Men able to preserve all life as we know it. Now, Stryker is back - and his extreme hatred for mutants rages as strong as ever. With a squad of mutant-hating mercenaries and the recruitment of Lady Deathstrike, Stryker tries once more to take down the X-Men - again attempting to break one of their own in the process.