This text presents a detailed description of the properties and clinical use of anticancer drugs. It provides information on all aspects of drug mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. Emphasis is placed on the rationale for the use of drugs in specific schedules and combinations, and guidelines are provided by dose adjustment in particular situations. This edition includes chapters on the following: endocinre therapies; antifolates; fluropyrimidines; cytidines and purine analogues; hydroxyurea; mitotic inhibitors; alkylating agents; antitumour antibiotics; anthracyclines; topoisomerase inhibitors; enzyme therapy; and anti-AIDS drugs.